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A total of 120 were collected out of which 60 were alcohol dependents and 60 were cannabis dependents that were diagnosed based on ICD-10 were selected from SMS Psychiatric Centre, Jaipur and other Psychiatric Centre of Jaipur. The purpose of this study is to find out emotional intelligence and self esteem of Alcohol Dependents and Cannabis Dependents. Assessment was done using Severity of Alcohol Dependents Questionnaire of Edwards (1978), Cannabis Use Disorder Identification Test (Adamson & Sellman, 2003), Raqon Emotional Intelligence Test (Roqan, 1971) and Rosenberg Self Esteem Scale (Rosenberg, 1965). To find out severity of alcohol dependence, cannabis dependence, emotional intelligence and self esteem of alcohol dependents & cannabis dependents. The result find alcohol dependents are poor in emotional intelligence and self esteem in comparing with cannabis dependents. The severity of alcohol dependence is negatively correlated with emotional intelligence and self esteem which tells us that with the increase in severity of dependence the emotional intelligence and self esteem of Alcohol Dependents were reduced. Similarly the severity of cannabis dependence is negatively correlated with emotional intelligence which signifies with the increase in severity of dependence the emotional intelligence of cannabis dependents were reduced but positively correlated with self esteem which acknowledge us that with the increase in severity of dependence the self esteem of cannabis dependents were increased.