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Background: Alcohol Dependence in some form has been a universal phenomenon. It is not only damages health of the addicted persons but also causes comprehensive damage to the family and marital life of concerned people. Marital violence, decreased marital relationship and interpersonal conflict are consequences seen in persons with alcohol dependence. Spouses of alcohol dependence individuals are likely to face problems in adjustment of marital life, family functioning and psychological health. Aim: Present study assesses and compares the marital adjustment in spouses of persons with and without alcohol dependence. Methods: The sample consisted of 100 spouses of persons with and without alcohol dependence (50 ADS and 50 without ADS) selected from OPD of Central India Institute of Mental Health and Neuro Sciences (CIIMHANS) by using purposive sampling method. Socio-demographic and clinical details of all the spouses of persons with and without Alcohol dependence assessed by using the Marital Adjustment Questionnaire (Kumar & Rohatgi, 1999). Result: The present Study has found significant difference in all domains (sexual, social and emotional) and overall marital adjustment in spouses of persons with and without alcohol dependence.