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Alcoholism is a global phenomenon. The consequences of alcoholism remain the same everywhere with little variation in the magnitude. In the present study, an attempt has been made to study the effect of cognitive behaviour therapy on quality of life of alcoholic dependents. This is a field experimental study in which the alcoholic dependents were given Cognitive Behaviour Therapy before and after administration of Quality of Life Scale. In the present research, cognitive behavior therapy was taken as the independent variable and quality of life was taken as dependent variable. The incidental purposive sampling technique was used in the selection of the sample. 60 alcohol-dependent patients were taken as a sample whose age ranged between 25 – 38 years. Results revealed that cognitive behaviour therapy has no impact on the psyche of the subjects because when they were getting opportunities for acquiring new information & skills, they were not able to make use of their thinking, learning, memory & concentration. They were possessing faith in religion & were thinking that the almighty will be taking care of them. It also shows that the subjects were reluctant and do not want to change their lifestyle.