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Physical disability is a very common part of human society and it comes in different forms. In addition to the well-known negative effects of these disabilities on the development of a child, such as motor development, inability to perform in educational settings and inability to communicate properly, they also have an effect in other areas of development such as behavioural, social and emotional development. The current study explored the comparison of possibility of onset of bipolar disorder between physically challenged children with that of normal children based on the Child Bipolar Questionnaire (CBQ) and the different factors affecting it. In the given sample, the difference in the distribution of the scores between physically challenged children and normal children is not statistically significant. In addition, the type of physically disability is not a statistically significant factor in the possibility of onset of bipolar disorder. Furthermore, it is also found that the type of family of a physically challenged child has a significant impact on the possibility of onset of bipolar disorder.