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The present study aimed to assess the level of adjustment of post-graduate science and social science students. It was hypothesized that post-graduate science students have lower adjustment than post-graduate social science students. It was also hypothesized that post-graduate social science male students have lower adjustment than post-graduate social science female students. Post-graduate science male students have lower adjustment than post-graduate science female students. In order to verify the above hypotheses a sample of 160 subjects with science and social-science background were selected from the Karnatak University Dharwad, Karnatak, India. Each group consist to 80 subjects with male (N=40) and female (N=40). To measure the adjustment, Adjustment Inventory developed and standardized by Asthana (1967) was administered individually, it has 42 items. The data were subjected to ‘t’ analyses and the major findings of the study revealed that the science post-graduate students have significantly higher level of adjustment than social-science post-graduate students. There is no significant difference between the male students of social science and science departments and also the female students of science departments. There is significant difference between the science male and science female students on adjustment pattern.