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Introduction: today a lot of efforts are exerted on decreasing psychological stress of women suffering from breast cancer by cognitive-behavioral training programs. Purpose: this study was done with the aim of examining efficacy of training stress-management by cognitive-behavioral method in decreasing stress symptoms of women suffering from breast cancer. Method: this study was a kind of semi-descriptive with pretest and posttest design and also following with control group in terms of applying goal and in terms of way of data collection. Statistical community is all those women that have already been identified to have breast cancer based on absolute identification of breast specialist and referred to cancer research centers of Shahid Beheshti University. From the respective statistical community, 14 women who had breast cancer were selected based on availability of choice and by various criteria and were assigned to two groups of control and experimental (each having seven people) by random assignment. The experimental group received training program through 10 sessions and the control group followed their usual plan. The research scale was 66-question version of Harry stress questionnaire. The data were analyzed by frequent measures. Findings: the results of research showed that applied intervention led to reducing the stress of women who suffered from breast cancer and this efficacy was stable over time. Conclusion: these findings represent that the stress in women having breast cancer can be reduced by training and also this method can be used as an intervention in reducing psychologically clinical symptoms of these people.