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Background burden of care can be conceptualized into two distinct components (objective and subjective). Objective burden of care is meant to indicate its effects on the household such as taking care of daily tasks, whereas subjective burden indicates the extent to which the caregivers perceived the burden of care. Aim of the present study was to assess level of burden and stigma on caretaker of schizophrenia and bipolar patients. Method researcher took N=80 samples from the population of schizophrenia and bipolar disorder. Researcher used ‘t’ test, ‘f’ test, correlation test, degree of freedom test to analyzed the data. Results researcher found that caretaker perceived higher stigma and burden, there will be no significant difference in education level. Twenty two (50.0 %) caretaker of schizophrenia perceived moderate to severe burden comparatively 9 (25.0 %) BMD (bipolar manic disorder) perceived moderate to severe burden. Researcher concluded that caretaker of schizophrenia and bipolar both perceived burden and stigma.