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Alcohol and drug use disorders have devastating physical, mental, and socio-economic consequences not only for patients but also for their families. Their illness substantially affects the quality of life of other family members, including financial security, mental health, social networks, and productivity. So the present study was an attempt to assess the relationship between family interaction pattern, family burden and Quality of life among caregivers of individuals with alcohol dependence. This study was conducted at the Ranchi Institute of Neuro-Psychiatry and Allied Sciences, Ranchi. It was a cross sectional study and purposive sampling was used. The present study consisted of 60 caregivers of alcohol dependence, those who were willing to participate and those who have satisfied with inclusion and exclusion criteria have been included in the study. The socio demographic data sheet had been used for collecting socio demographic details of the caregivers of individuals with alcohol dependence. To assess the alcohol severity of the patient, the alcohol severity index scale was applied. Family interaction pattern scale, family burden interview schedule and WHO Quality of life scale were applied on the caregivers of individuals with alcohol dependence. The findings indicated that there is significant positive correlation exist between family interaction pattern, Family burden and quality of life among caregivers of individuals with alcohol dependence.