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Aim: The present case study looks at the effectiveness of Meta Model of Neuro Linguistic Programming (NLP) for therapeutic treatment of Clinical Depression. Method: The present case-study is a qualitative research on 18 years old teenager, clinically diagnosed with Moderate Depression using Beck’s Depression Inventory-II, and received Neuro Linguistic Programming Sessions thrice a week over a duration of 2 months (18 sessions - 60 minutes each). Evaluation was done by comparing the scores of Becks Depression Inventory-II at the time of joining with progress at 2 months of therapeutic treatment. Comparisons were made for Depressed Mood, Loss of interest & Enjoyment, increased fatigability, performance in Work related activities and Social Engagements, and Worries. Techniques of Meta Model were used for delivering therapeutic treatment. Results: The BDI-II score recorded at the time of joining was 29 and at the end of18thsession, the scores dipped down to 10. Hence, result evidenced that consistent application and training of techniques of Meta Model (Neuro Linguistic Programming) can be used as an effective treatment of moderate depression.