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Background: Addictive behavior could be defined as any activity, substances, object or behavior that has become the major focus of a person’s life to the exclusion of other activities or that has begun to harm individually, physically, mentally or socially. These behaviors increase the risks of diseases associated with personal and social problems. They are often experienced subjectively as loss of control, meaning the behavior continues to occur despite volitional attempts to abstain it. Material and Methods: In the present study 560 representative samples out of which 280 were substance-dependent & 280 Non-dependent drawn from the general population, drug addiction institute & rehabilitation centre selected from Chhattisgarh. The study was concentrated on male substance dependent & non-dependent between, the age group ranged between 18-50 years and involved in different type of profession, individuals having history of any neurological disorder, mental disorder,  physical disorder and psychological before starting the drug were excluded from the study. Conclusion: Family history of addiction plays a significant role for substance intake. Alcohol intake was more among police and Businessman whereas cannabis intake was more among Teachers and Doctors. Addiction affects psycho-physical health.