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Introduction: Psycho-spiritual well-being is an area of interest to researchers all over the world. Individuals with high and low spiritual wellbeing portray substantially different personality profiles. Creating and keeping sense of spiritual well-being has a vital role in adaptation to the stress. Material and Methods: A Quantitative research approach was selected to achieve the objectives of the study. 250 Nursing students were selected by using purposive sampling technique and data was gathered by using a structured Questionnaire to collect socio-demographic data and The Spiritual Intelligence Self Inventory Report-24 Scale was used to gather information regarding spiritual intelligence and RYFF’S to assess Psychological well-being. The data was analysed by using descriptive (frequency percentages, mean and standard deviation) and inferential statistics (chi-square), Spearman‘s rank correlation was used to identify the relationship between Spiritual Intelligence and Psychological Wellbeing. Result: The obtained mean and Standard deviation of spiritual intelligence among the nursing students with regard to critical existential thinking was 13.84±6.07. With regard to personal meaning production, it was 11.78 -±3.38; with regard to transcendental awareness was 15.61 ± 3.77and With regard to conscious state expansion 11.68 + 3.76. The obtained mean value and standard deviation of psychological wellbeing among the Nursing students; Concerned to, autonomy, 22.7 + 6.95; With regard to Environmental mastery, 25.48 + 4.72; With regard to Personal Growth, 25.77 + 4.80; With regard to Positive Relations, 25.60 + 4.66; With regard to Purpose of life, 24.75 + 5.02; With regard to the Self-acceptance, 25.12 + 4.35.There was a significant association between spiritual intelligence and marital status (x211.34). Significant association was also seen between Psychological well-being and Age (x2 20.54), Gender (x2 10.75) and marital status (x2 1312.7). There was moderately positive correlation between Spiritual Intelligence and Psychological well-being (r= 0.99). Conclusion: Spiritual well-being can reinforce psychological functions and adaptation.