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The present study was undertaken to investigate, (1) Is there any relationship between stress and alienation? (2) Is there any difference between orphans and normal with respect to stress? (3) Is there any difference among orphans and normal with respect to alienation? In addition to these main objectives of the present research are, (1) To find out any relationship between stress and alienation,  (2) To find out whether or not orphans and normal significantly differ with respect to stress, (3) To find out whether or not orphans and normal significantly differ with respect to alienation. In this study 40 subjects in each group were analysed which means that there are total 80 subjects in this study. Perceived Stress Scale (PSS, Cohen et. al., 1983) and Alienation Scale by R. V. Patil were used for the collection of data. In order to find out these objectives Pearson correlation and t-test was applied. The results indicated that stress and alienation are highly correlated with each other which means that when a person is under stressful condition they automatically get into alienated and vice versa. Results from t-test clearly show that orphans are higher in alienation and stress in comparison to normal.