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Pain results from complex interplay of biological, psychological & sociocultural factors. There are gamuts of medical and psychosocial factors which cause pain. The advent of technology and inordinate and improper use of computers and its components like key board and mouse are also associated with pain. It has been found both on the basis of research and clinically that software professionals often consult physicians for pain in different site of their body more specifically fingers, upper limbs, neck and forehead. This medical condition is known as Repetitive Strain Injury (RSI). It might result because of repetitive tasks, mechanical compressions or sustained or awkward positions. The patients of this medical condition often experience inflammation at different sites of body parts which are often involved in using computers. Unhealthy bodily postures are also associated with an issue. Pain is basically a sensory, emotional and subjective experience. High psychological arousal and cognitive set are significant factors which maintain or exacerbate the pain. In this paper, Behavioral management of pain specifically refers to brief cognitive, behavioral and mindfulness based psychological interventions in pain management. The current paper focuses on psychological factors related to pain and presented a case with RSI in holistic pain management and highlights the importance of incorporating biopsychosocial model in pain management for speedy recovery and better quality of life of patient.