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The prevalence of psychological disturbances in medical undergraduate students has been reported from various countries. Very few studies regarding student distress reported from India. Therefore, we conducted this study to determine the presence of depression, anxiety and stress among medical students in MNR Medical College, Sangareddy, Telengana. In this cross-sectional study, we recruited 257 students from MNR Medical College after obtaining written voluntary consent. DASS 42 questionnaire was used to collect information on basic demographic. Scores for each of the respondents were calculated as per the severity- rating index. Data was analysed by SPSS 20.0. DASS scores were slightly higher in males than female, but it was not statistically significant. Depression, anxiety and stress in students has high negative effect in their social and personal lives. So there is a need for urgent attention to the psychological well-being of undergraduate medical students to improve their life style.