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This study aims to determine and find out the significant difference between high and low Organizational health, Job-involvement and Work-satisfaction among Supervisors of Pharmaceutical Organizations. The sample was drawn by random method. The total samples comprised 240 Supervisors of different types Pharmaceutical organizations were selected by this aim of research. The equal number of Supervisors was selected. The data Selection producer of sample were selected by random technique from different Pharmaceutical organizations managers located Anand, Ahmedabad and Vadodara in Gujarat state. O.H, J.I and W.S scale were administered to measure the Supervisors of Pharmaceutical Organizations. Data was analyzed by using means, standard deviations and t test. The result reveal that there is a significant interaction between Supervisors of from Pharmaceutical organizations in different factors and their levels of organizational health, work satisfaction and job-involvement and all three variables in developed closely relation to Supervisors of Pharmaceutical Organizations.