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Quality of life includes the physical, functional, social and emotional well being of an individual. Coping strategy is one’s flexibility in using different strategies according to the multiple situational demands is sown in empirical research to have an overall reduction in observable stress (Sideridus, 2006). The poor quality of life is associated with depression and obsessive compulsive disorder. Thus, the present study aims to see the quality of life and copying strategies in depression and obsessive compulsive disorder. It consists of 30 participants purposively selected from government hospitals across Gandhinagar and Ahmedabad. The participants were assigned in two groups’ i.e Depression (15) and OCD (15). The respondents were assessed using quality of life questionnaire, Y-BOCS severity scale, Beck depression inventory and coping strategy inventory which was administered individually. There is no significant difference between the two groups on Coping Strategies and Quality of Life. It is found that Cognitive Restructuring and Social Support are negatively correlated with Depression. There is significant negative correlation between Problem Focused Engagement, Emotion Focused Engagement, cognitive strategy, Engagement, Quality of Life with depression. Whereas it shows no significant correlation between OCD and coping strategy and OCD and Quality of Life.