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This research paper is an attempt to study the level of psychological Well-being in HIV/AIDS patients and normal persons .This study is based on sample of 100 subjects 50 HIV/AIDS patients (25 males and 25 females) and 50 subjects were normal person’s (25 males and 25 females). The psychological well-being of HIV/AIDS positive and negative persons were measured by psychological Well-being scale (PWBS) (HINDI) adopted by S. N. Rai & Deepika Gupta Department of Psychology Chaudhary Charan Singh University Meerut. Three independent variables were studied i.e. gender, normality and HIV/AIDS. Mean, S.D and t-test were applied for data analysis. The results reveal that the all three independent variables i.e. gender, normality and HIV/AIDS are found significant at .01 level of confidence. This study shows that there is significant difference between the Psychological Well-being of HIV/AIDS patients and normal’s. Significant difference between six areas of psychological Well-being (Self-acceptance, personal growth, purpose in life, environmental mastery, autonomy, positive relations with others) among HIV/AIDS patients and normal’s were found. Also significant difference was found between male and female HIV/AIDS patients.