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Background: 2 decades of research had found that comorbid disorders occur in children with ADHD more than by chance. The role of comorbidities in influencing the self-esteem of children with ADHD is still less explored. Aims: To study the various domains of self-esteem in children with ADHD and to evaluate the effect of comorbidities on low self-esteem in ADHD children. Methods And Materials: 60 subjects aged 6 to 16 years who were diagnosed based on DSM IV as ADHD were recruited with informed consent, from tertiary care hospital for a period of 6 months by consecutive sampling. Based on detailed interview of subjects and parents using the Semi structured assessment schedule K- SADS - PL for comorbidities, children with ADHD were grouped as those with and without comorbidities. While severity of ADHD was assessed by Conner’s Parent’s 10 item abbreviated index, self-esteem was assessed by Culture free self-esteem inventory. Results: Parent related self-esteem was lower in ADHD children with comorbid internalizing disorders when compared to ADHD children with comorbid externalizing disorders. Higher severity of ADHD and longer duration of ADHD correlated with lower self-esteem, (especially social domain). Conclusions: Comorbidities definitely influence the level of self-esteem in children with ADHD, but other factors also need to be considered for optimal management of low self-esteem.