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The purpose of the study was to examine school based risk factors promoting drug among students in Public Secondary Schools in Molo Sub- County, Kenya. The study used a mixed methods embedded research design. The study used a sample of 120 participants from five schools sampled out of 26 schools through probability and non-probability sampling. The study used questionnaires and interview guide as the major instruments for data collection. The quantitative data were analyzed descriptively while qualitative data were transcribed, coded and analyzed in themes and narratives. The study identified peer pressure, poor communication, family stress, conflict with school management, social network sites and violence as the major risk factors for drug abuse among secondary school students. The research recommended further study to be conducted on factors contributing to the psychological well-being of students in schools in Molo Sub- County.