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Purpose of the study was examined the role of psychosocial variables on lack of negative thought of adolescents with sickle cell anemia (AS) type. 200 participants of sickle cell anemia (AS) type were consisted, coming from age group 13 to 18 yrs of Chhattisgarh state. General wellbeing scale and social support scale was applied as a questionnaire for data collection. The result showed that multiple correlation coefficient R was found to be .475 which is significant (F = 32.988, p<.01). Its square is .226 which indicates that significant variables included in the present analysis (i.e. emotional support, informational support and gender) contributed 22.6% variance in lack of negative thought of sickle cell anemic (AS Type) adolescents. It is observed that practical support contributed 14.3% (R2 Change =.143), family income contributed 3.3% (R2 Change =.033), informational support contributed 3.1% (R2 Change =.031), and gender contributed 1.9% (R2 Change =.019) variance of lack of negative thought in the subjects.