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Background and Objectives: Children with autism have many problems, and then it is necessary to identify and strengthen those factors that reduce the vulnerability of autistic children against problems. Therefore this study was conducted aimed to investigating the effectiveness of clinical model of therapeutic creativity on cognitive flexibility in children with autism. Methods: The research design of this study was semi-experimental type as pretest-posttest with control group. The studied sample was including 16 children with autism who were selected through convenience sampling method and were categorized randomly into two groups of experiment and control. Cognitive Flexibility Inventory (CFI) was used for data collection and data analyzing was conducted with univariate analysis of covariance and using SPSS-21 software. Results: The results showed that clinical model of therapeutic creativity have significant effect on improving cognitive flexibility (F= 5.11, p< 0.05) in children with autism. Conclusion: According to the results of this study, clinical model of therapeutic creativity can be suggested as an effective method in improving cognitive flexibility of autistic children.