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Substance use estimates, however, are liable to change over time, depending upon diverse factors such as availability and cost of the substances in the community, existing legislations and their implementation, social perception and attitude about use of particular substances, peer pressure and other socio-cultural factors. About 122 drug dependence treatment centres or De-Addiction Centres (DACs) have been established by The Ministry of Health and Family Welfare (MOH&FW), Government of India. While most of these government centres are associated with either general hospitals at the district levels (district hospitals or civil hospitals), some have also been attached with departments of Psychiatry at certain medical colleges. Only a few centres (about 42, mainly those in the north-eastern states of the country) receive recurrent grants from the union health ministry. Most others have been dependent on the state governments for the recurring expenditure (on staff salaries, supplies etc.).