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| Published: September 23, 2020

COVID-19 therapeutic and prevention aminoquinolines against coronavirus disease (COVID-19): chloroquine or hydroxychloroquine review

Azhagu Madhavan S

PG & Research Deparment of Zoology & Biotechnology, A.V.V.M. Sri Pushpam College (Autonomous) Poondi, Thanjavur, India Google Scholar More about the auther

, Vinotha P

PG & Research Department of Bio-Chemistry,Meenakshmi Chandrasekaran College of Arts and Science, Karambayam, Pattukkottai, Thanjavur District,Tamilnadu, India Google Scholar More about the auther

, Uma V

Sri Sai Apollo Educational Insttute, Bio-Chemistry.Veppur- 60634, Cuddalore District, Tamilnadu, India Google Scholar More about the auther

, Ganesan S

PG & Research Deparment of Zoology & Biotechnology, A.V.V.M. Sri Pushpam College (Autonomous) Poondi, Thanjavur, India Google Scholar More about the auther

, Senthil J

Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India Google Scholar More about the auther

DIP: 18.01.121/20200803

DOI: 10.25215/0803.121

ABSTRACT

The ongoing development of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is liable for an overall pandemic. Given the worldwide wellbeing crisis, medicate repositioning is the most solid alternative to plan a proficient treatment for contaminated patients immediately. The initial step of the viral replication cycle. The patient evade mechanical airing along with gain a prompt clinical and radiological improvement, after treatment of escalate plasma trade (PE) trailed by intravenous immunogloblin (IVIG). sort of COVID-19, may require serious consideration treatment or even consider, the utilization of mechanical ventilation for patients with respiratory disappointment. The rate and death rates were corresponded with DCI, particularly in nations with neighborhood transmission. By and large, this starter report shows us the underlying epidemiological discoveries of COVID-19, however persistent checking of patients with this illness is still justified. The ID of this new mechanism of activity of CLQ and CLQ-OH bolsters the utilization of these repositioned medications to fix patients contaminated with SARS-CoV-2. The in-silico approaches utilized in this investigation may likewise be utilized to survey the effectiveness of an expansive scope of repositioned or potentially imaginative medication applicants before clinical assessment. In addition, it might improve poor clinical results of these patients.

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Azhagu Madhavan S @ mathavan062@gmail.com

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Article Overview

ISSN 2348-5396

ISSN 2349-3429

18.01.121/20200803

10.25215/0803.121

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Published in   Volume 08, Issue 3, July-September, 2020