Investigation the Relative Expression of Genes of ATPase Family in Major and Regular Depressed Patients

To develop new pharmaceutical strategies in a comprehensive manner, it is necessary to understand the reasons for major depression. Present paper aims for comparison of expression of ATPase families in major depressed and normal people. Statistical population of this research includes all depressed people coming to professional clinic of Shahryar in 2014-15. This contains 47 depressed patients which were selected based on accessibility from those visiting clinic. 26 normal people were selected as comparison group as well. To study the relative expression of ATPase1-3, quantitative measurement method using Real-Time RT-PCR was used. Relative expression of ATPase2 showed a significant reduction compared to normal people (p<0.02). In patients, ATPase1 had higher relative expression compared to normal people. However, ATPase had no significant difference among patients and normal people. Results demonstrate that ATPase1 and ATPase2 are important variables in depression but ATPase3 plays no pivotal role in this regard.